Thermo Fisher Scientific RNF20 Monoclonal Antibody (OTI2B9), TrueMAB
RNF20 단백질을 인식하는 Mouse IgG2b 단일클론 항체로 Western blot 및 IHC(P) 적용 가능. 인간 RNF20(aa 493-754) 재조합 단백질을 면역원으로 사용. 액상 형태, 1 mg/mL 농도, PBS/BSA/glycerol 버퍼에 보존. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2B9 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 493–754 of human RNF20 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
RNF20 is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B.
It selectively suppresses the expression of certain protooncogenes and growth-related genes, including those induced by epidermal growth factor, by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS).
Conversely, RNF20 positively regulates the p53 tumor suppressor and numerous histone H2A and H2B genes.
Together with the deubiquitinase USP44, RNF20 modulates stem cell differentiation through H2B monoubiquitination.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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