Thermo Fisher Scientific COX1 Recombinant Rabbit Monoclonal Antibody (ARC0960)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:6,000

-

Immunocytochemistry (ICC/IF)

1:100

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

ARC0960

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 50-150 of human COX1/PTGS1 (P23219) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:COX1,uniProtId:P23219-1,ncbiNodeId:9606,antigenRange:50-150,antigenLength:599,antigenImageFileName:MA5-35479_COX1_P23219-1_Rabbit.svg,antigenImageFileNamePDP:MA5-35479_COX1_P23219-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2849380

Product Specific Information

Immunogen sequence: GLDRYQCDCT RTGYSGPNCT IPGLWTWLRN SLRPSPSFTH FLLTHGRWFW EFVNATFIRE MLMRLVLTVR SNLIPSPPTY NSAHDYISWE SFSNVSYYTR I

Target Information

PTGS1 (COX1, Cyclooxygenase 1) is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes PTGS1, which regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis. Alternative splicing of this gene generates two transcript variants. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.