Thermo Fisher Scientific DDR2 Recombinant Rabbit Monoclonal Antibody (ARC0958)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:6,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

ARC0958

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 756-855 of human DDR2 (Q16832) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:DDR2,uniProtId:Q16832-1,ncbiNodeId:9606,antigenRange:756-855,antigenLength:855,antigenImageFileName:MA5-35477_DDR2_Q16832-1_Rabbit.svg,antigenImageFileNamePDP:MA5-35477_DDR2_Q16832-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2849378

Product Specific Information

Immunogen sequence: WESILLGKFT TASDVWAFGV TLWETFTFCQ EQPYSQLSDE QVIENTGEFF RDQGRQTYLP QPAICPDSVY KLMLSCWRRD TKNRPSFQEI HLLLLQQGDE

Target Information

DDR2 is a member of a subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. DDR1 and DDR2 have been shown to be potently inhibited by Gleevec. DDR2 required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.