Thermo Fisher Scientific PLA2R1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 870-1130 of human PLA2R1 (NP_0313923) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PLA2R1,uniProtId:Q13018-1,ncbiNodeId:9606,antigenRange:870-1130,antigenLength:1463,antigenImageFileName:PA5-87610_PLA2R1_Q13018-1_Rabbit.svg,antigenImageFileNamePDP:PA5-87610_PLA2R1_Q13018-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.37 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.09% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2804287

Product Specific Information

Immunogen sequence: GASWWIGLQE ERANDEFRWR DGTPVIYQNW DTGRERTVNN QSQRCGFISS ITGLWGSEEC SVSMPSICKR KKVWLIEKKK DTPKQHGTCP KGWLYFNYKC LLLNIPKDPS SWKNWTHAQH FCAEEGGTLV AIESEVEQAF ITMNLFGQTT SVWIGLQNDD YETWLNGKPV VYSNWSPFDI INIPSHNTTE VQKHIPLCAL LSSNPNFHFT GKWYFEDCGK EGYGFVCEKM QDTSGHGVNT SDMYPMPNTL EYGNRTYKII N; Positive Samples: 293T, SH-SY5Y, Mouse liver, Mouse heart; Cellular Location: Cell membrane, Single-pass type I membrane protein

Target Information

Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.