Thermo Fisher Scientific CD205 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 216-501 of human LY75 (NP_0023402) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CD205,uniProtId:O60449-1,ncbiNodeId:9606,antigenRange:216-501,antigenLength:1722,antigenImageFileName:PA5-87607_CD205_O60449-1_Rabbit.svg,antigenImageFileNamePDP:PA5-87607_CD205_O60449-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.15 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2804286

Product Specific Information

Positive Samples: Mouse lung; Cellular Location: Membrane, Single-pass type I membrane protein

Immunogen sequence: CEDNWEKNEQ FGSCYQFNTQ TALSWKEAYV SCQNQGADLL SINSAAELTY LKEKEGIAKI FWIGLNQLYS ARGWEWSDHK PLNFLNWDPD RPSAPTIGGS SCARMDAESG LWQSFSCEAQ LPYVCRKPLN NTVELTDVWT YSDTRCDAGW LPNNGFCYLL VNESNSWDKA HAKCKAFSSD LISIHSLADV EVVVTKLHNE DIKEEVWIGL KNINIPTLFQ WSDGTEVTLT YWDENEPNVP YNKTPNCVSY LGELGQWKVQ SCEEKLKYVC KRKGEKLNDA SSDKMC

Target Information

CD205 (LY25, Lymphocyte Antigen 75) is an integral membrane glycoprotein involved in antigen uptake, trafficking and presentation that improves the induction of antigen-specific T cell immunity. CD205 is highly expressed by CD8+ dendritic cells (DCs) and also expressed at different levels by bone marrow Gr1+ cells, Langerhans cells, (BMDC) bone marrow derived DCs and thymic epithelial cells. CD205 acts as an endocytic receptor that directs captured antigens to the extracellular space towards a specialized antigen processing region. Further, CD205 also prompts the reduced proliferation of B lymphocytes. Diseases associated with CD205 dysfunction include pneumonic plague and lipid pneumonia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.