Thermo Fisher Scientific PERP Polyclonal Antibody
Rabbit polyclonal antibody targeting human PERP protein (aa 37-50). Validated for Western blot (1:500–1:1,000). Useful for studying p53-mediated apoptosis pathways. Supplied as 1 mg/mL liquid, stored at 4°C short term or -20°C long term.
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Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Amino acids 37–50 of the human PERP protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2161823 |
Target Information
The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in the p53 network, including Chk2, p53R2, p53AIP1, Noxa, PIDD, PID/MTA2, MTBP, and PERP, have been identified and cloned.
PERP (also known as PIGPC1 and THW) is a plasma membrane protein. p53 binds to the promoter of PERP and transcriptionally activates the PERP gene, leading to the translation of PERP protein, which mediates p53-induced apoptosis. The expression of PERP induces cell death and functions as a mediator of p53-dependent apoptosis. PERP shares sequence similarity with PMP-22/gas3 and is a member of the PMP-22/gas3 family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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