Thermo Fisher Scientific RASD2 Polyclonal Antibody
Human RASD2 단백질을 인식하는 Rabbit Polyclonal 항체로, WB 및 IHC(P) 실험에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS buffer와 glycerol로 안정화된 액상 형태입니다. 뇌 발달 및 종양혈관 연구에 유용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human TEM2. Recombinant protein control fragment (Product # RP-91332) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2648372 |
Product Specific Information
Immunogen sequence:
DTSGNHPFPA MRRLSILTGD VFILVFSLDN RESFDEVKRL QKQILEVKSC LKNKTKEAAE LPMVICGNKN DHGELCRQVP TTEAELLVSG DENCAYFEVS AKKNTNVDEM FYVLFSMAKL PHEMSPALHR KISVQYGDAF HPRPFCMRRV KEMDAYGMVS PFARRPSVNS DLKYIKAKVL R
Sequence identity:
Highest antigen sequence identity to the following orthologs:
- Mouse: 94%
- Rat: 94%
Target Information
Rhes, also known as tumor endothelial marker 2 (TEM2), is a small GTP-binding protein predominantly expressed in the striatal region of the brain. This protein belongs to the RASD subfamily of Ras-related GTP-binding proteins and is thought to play a role in normal brain development and function. Mice lacking this gene show increased anxiety levels and motor coordination deficits.
Rhes was identified as TEM2 through analysis of genes upregulated in tumor endothelium. Tumor endothelial markers are significantly upregulated during angiogenesis and neoangiogenesis, which are crucial for solid tumor growth. TEMs localized on the cell surface and conserved across species are of particular interest for the development of anti-angiogenic therapies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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