Thermo Fisher Scientific CCDC88C Polyclonal Antibody
Human CCDC88C 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P)에서 1:200~1:500 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS(40% glycerol, 0.02% sodium azide) 용액 형태로 제공. Wnt 신호전달 경로 연구에 적합.
- 카탈로그번호
- PA552215
- 판매단위
- pk
카탈로그
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CCDC88C. Recombinant protein control fragment (Product # RP-89015) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2639499 |
Product Specific Information
Immunogen sequence:
SSLESSRNTS SNSSPLNLKG SSEQLHGRSE SFSSEDLIPS RDLATLPREA STPGRNALGR HEYPLPRNGP LPQEGAQKRG TAPPYVGVRP CSASPSSEMV TLEEFLEESN RSSPTHDTPS CRDDLLSD
- Highest antigen sequence identity to the following orthologs:
- Mouse: 77%
- Rat: 79%
Target Information
This gene encodes a ubiquitously expressed coiled-coil domain-containing protein that interacts with the disheveled protein and acts as a negative regulator of the Wnt signaling pathway.
The encoded protein contains a PDZ-domain binding motif in its C-terminus, allowing interaction with the disheveled scaffold protein, which is critical in regulating Wnt signaling.
The Wnt pathway is essential for embryonic development, tissue maintenance, and cancer progression.
Mutations in this gene are associated with autosomal recessive, primary non-syndromic congenital hydrocephalus, characterized by excessive cerebrospinal fluid accumulation in brain ventricles.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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