Thermo Fisher Scientific EXD2 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Immunogen sequence:
TSCHAISNYY DNHLKQQLAK EFQAPIGSEE GLRLLEDPER RQVRSGARAL LNAESLPTQR KEELLQALRE FYNTDVVTEE MLQEAASLET RISNENYVPH GLKVVQCH

Highest antigen sequence identity to the following orthologs:

• Mouse: 90%
• Rat: 92%

Target Information

Exonuclease that has both 3′–5′ exoribonuclease and exodeoxyribonuclease activities, depending on the divalent metal cation used as cofactor (PubMed:29335528, PubMed:31127291).

• In presence of Mg²⁺: only shows 3′–5′ exoribonuclease activity.
• In presence of Mn²⁺: shows both exoribonuclease and exodeoxyribonuclease activities.
  Acts as an exoribonuclease in mitochondria, possibly regulating ATP production and mitochondrial translation (PubMed:29335528).
  Also involved in the response to DNA damage (PubMed:26807646, PubMed:31255466).
  Functions as 3′–5′ exodeoxyribonuclease for double-strand breaks resection and efficient homologous recombination (PubMed:20603073, PubMed:26807646).
  Plays a key role in controlling chromosomal break repair, recruited to chromatin in a damage-dependent manner, and interacts with the MRN complex to accelerate resection through its 3′–5′ exonuclease activity (PubMed:26807646).
  Also involved in response to replicative stress: recruited to stalled forks and required to stabilize and restart stalled replication forks by restraining excessive fork regression, thereby suppressing degradation (PubMed:31255466).
  [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.