Thermo Fisher Scientific CD91 Monoclonal Antibody (A2MR-a2), PE, eBioscience
인간 CD91(LRP-1) 인식용 단클론 항체로, Flow Cytometry 분석에 최적화됨. PE 형광 표지로 높은 감도와 재현성 제공. 다양한 세포 유형에서 CD91 발현 검출 가능. 4°C 암조건 보관, 동결 금지.
- 카탈로그번호
- 12-0919-4x (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD91 Monoclonal Antibody (A2MR-a2), PE, eBioscience
Thermo Fisher Scientific CD91 Monoclonal Antibody (A2MR-a2), PE, eBioscience™
Applications
- Flow Cytometry (Flow)
Tested Dilution: 5 µL (0.06 µg)/test
Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), PE, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | A2MR-a2 |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2572570 |
Additional Formats
- eFluor 660
- NovaFluor Blue 610-70S
- NovaFluor Blue 660-120S
- NovaFluor Red 710
- NovaFluor Red 725
- NovaFluor Yellow 660
- NovaFluor Yellow 730
- NovaFluor Yellow 755
- PerCP-eFluor 710
- Super Bright 600
- Request custom conjugation
Product Specific Information
The A2MR-a2 monoclonal antibody reacts with human CD91, also known as LRP-1 and alpha-2 macroglobulin receptor. CD91 is a 600 kDa, type 1 transmembrane protein consisting of an alpha and beta chain.
- The alpha chain interacts with multiple structurally and functionally diverse ligands.
- The beta chain contains tyrosine phosphorylation motifs that interact with adaptor and signaling proteins.
- CD91 mediates ligand endocytosis and trafficking to lysosomes.
- Expressed by monocytic lineage cells, dendritic cells, hepatocytes, fibroblasts, adipocytes, neurons, and syncytiotrophoblast.
- Plays a role in cross-presenting antigens via MHC class I molecules after endocytosis of heat shock protein-peptide complexes.
- Involved in cell migration and activation of signaling cascades.
Applications Reported: Use in flow cytometric analysis.
Applications Tested: Pre-titrated and validated by flow cytometric analysis of normal human peripheral blood cells.
Recommended usage: 5 µL (0.06 µg) per test (100 µL final volume, 10⁵–10⁸ cells/test).
Excitation: 488–561 nm
Emission: 578 nm
Laser Compatibility: Blue, Green, Yellow-Green
Filtration: 0.2 µm post-manufacturing filtered
Target Information
The encoded protein is an endocytic receptor involved in intracellular signaling, lipid homeostasis, and clearance of apoptotic cells.
It is essential for A2M-mediated clearance of amyloid precursor protein and beta-amyloid, major components of amyloid plaques in Alzheimer’s disease.
Expression decreases with age and is lower in Alzheimer patient brain tissue compared to controls.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.