Thermo Fisher Scientific CD91 Monoclonal Antibody (A2MR-a2), PE, eBioscience

Thermo Fisher Scientific CD91 Monoclonal Antibody (A2MR-a2), PE, eBioscience™

Applications

• Flow Cytometry (Flow)

Tested Dilution: 5 µL (0.06 µg)/test
Publications: View 1 publication

Product Specifications

Additional Formats

• eFluor 660
• NovaFluor Blue 610-70S
• NovaFluor Blue 660-120S
• NovaFluor Red 710
• NovaFluor Red 725
• NovaFluor Yellow 660
• NovaFluor Yellow 730
• NovaFluor Yellow 755
• PerCP-eFluor 710
• Super Bright 600
• Request custom conjugation

Product Specific Information

The A2MR-a2 monoclonal antibody reacts with human CD91, also known as LRP-1 and alpha-2 macroglobulin receptor. CD91 is a 600 kDa, type 1 transmembrane protein consisting of an alpha and beta chain.

• The alpha chain interacts with multiple structurally and functionally diverse ligands.
• The beta chain contains tyrosine phosphorylation motifs that interact with adaptor and signaling proteins.
• CD91 mediates ligand endocytosis and trafficking to lysosomes.
• Expressed by monocytic lineage cells, dendritic cells, hepatocytes, fibroblasts, adipocytes, neurons, and syncytiotrophoblast.
• Plays a role in cross-presenting antigens via MHC class I molecules after endocytosis of heat shock protein-peptide complexes.
• Involved in cell migration and activation of signaling cascades.

Applications Reported: Use in flow cytometric analysis.
Applications Tested: Pre-titrated and validated by flow cytometric analysis of normal human peripheral blood cells.
Recommended usage: 5 µL (0.06 µg) per test (100 µL final volume, 10⁵–10⁸ cells/test).

Excitation: 488–561 nm
Emission: 578 nm
Laser Compatibility: Blue, Green, Yellow-Green
Filtration: 0.2 µm post-manufacturing filtered

Target Information

The encoded protein is an endocytic receptor involved in intracellular signaling, lipid homeostasis, and clearance of apoptotic cells.
It is essential for A2M-mediated clearance of amyloid precursor protein and beta-amyloid, major components of amyloid plaques in Alzheimer’s disease.
Expression decreases with age and is lower in Alzheimer patient brain tissue compared to controls.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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