Thermo Fisher Scientific FERMT3 Monoclonal Antibody (OTI2G2), TrueMAB
FERMT3 단백질을 인식하는 Mouse monoclonal antibody로, Western blot 및 IHC(P) 분석에 적합합니다. Human 시료에 반응하며, 고순도 친화 크로마토그래피 정제 제품입니다. 안정적인 PBS/BSA/glycerol buffer에 보존되며 연구용으로 사용됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2G2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 259–528 of human FERMT3 produced in E. coli. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
The three KINDLINs are a novel family of focal adhesion proteins that localize to integrin adhesion sites. These proteins contain a centrally located FERM domain interrupted by a pleckstrin homology (PH) domain.
KINDLIN1 and KINDLIN2 play essential roles in integrin-mediated adhesion and spreading. In contrast, KINDLIN3 expression is restricted to hematopoietic cells, being abundant in megakaryocytes and platelets.
Transcriptional misregulation of KINDLINs has been reported in various cancers. Studies indicate that KINDLIN3 is crucial for platelet integrin activation and integrin outside-in signaling, suggesting it may serve as a therapeutic target for modulating integrin activation in platelets and leukocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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