Thermo Fisher Scientific INSR alpha Chimeric Recombinant Rabbit Monoclonal Antibody (83-14)
INSR alpha의 세포외 도메인을 인식하는 재조합 토끼 단일클론 항체. Western blot, IHC, ICC, Flow cytometry 등 다양한 응용에 적합. HEK293 발현 시스템에서 생산되었으며 Protein A로 정제. 단기 4°C, 장기 -20°C 보관 권장.
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Thermo Fisher Scientific INSR alpha Chimeric Recombinant Rabbit Monoclonal Antibody (83-14)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (IHC) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | 10 µg/mL |
| ELISA | Assay-dependent |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Bovine, Human, Sheep, Pig |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 83-14 |
| Immunogen | Raised by immunizing mice with IM-9 lymphocytes followed by purified insulin receptor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_3074239 |
Product Specific Information
Specificity: Recognises the extracellular domain of the Insulin Receptor alpha, amino acids 469-592 (exon 7 and 8).
Target Information
The biological actions of insulin and IGF-1 are mediated by their respective cell surface receptor tyrosine kinases, which regulate multiple signaling pathways through phosphorylation cascades. Insulin/IGF-1 binding to the extracellular domain leads to autophosphorylation of downstream target proteins. Variations in sequence between these receptors confer ligand specificity and differences in intracellular signaling domains, resulting in distinct functional outcomes. Defects in IR cause insulin resistance syndromes, while IGF-1R defects may result in growth retardation. Both signaling cascades play critical roles in cancer development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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