Thermo Fisher Scientific Cytokeratin 18 (KRT18) Monoclonal Antibody (SPM265)
인간 세포에서 Cytokeratin 18을 검출하는 단클론 항체로, 다양한 면역분석(WB, IHC, ICC, Flow 등)에 사용 가능. Mouse IgG1, kappa 형식이며 Protein A/G로 정제됨. 비결합형 액상 제품으로 4°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC-P) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC-PFA) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
| Immunomicroscopy (IM) | Assay-dependent |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SPM265 |
| Immunogen | PMC-42 human breast carcinoma cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Does not react with Mouse, Rat, Sheep, Hamster, Cow, Dog, or Pig.
Target Information
Cytokeratin 18 (Keratin 18, KRT18, type I cytoskeletal 18) belongs to the type A (acidic) subfamily of low molecular weight keratins and exists in combination with cytokeratin 8.
It is expressed in epithelial tissues of the gastrointestinal, respiratory, and urogenital tracts, as well as in endocrine and exocrine tissues and mesothelial cells.
Cytokeratin 18 is primarily found in non-squamous epithelia and is present in most adenocarcinomas and ductal carcinomas, but not in squamous cell carcinomas.
Hepatocellular carcinomas express only cytokeratins 8 and 18. Mutations in the KRT18 gene are associated with cryptogenic cirrhosis.
Two transcript variants encoding the same protein have been identified.
Cytokeratin expression patterns assist in distinguishing epithelial malignancies and are valuable in differential diagnosis using immunohistochemistry, cytopathology, and flow cytometry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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