Thermo Fisher Scientific ICAM-1 (CD54) Polyclonal Antibody
인간 ICAM-1(CD54)을 인식하는 Goat Polyclonal 항체로, ICC/IF에 적합합니다. 비결합형 액상 형태이며, 0.5 mg/mL 농도로 제공됩니다. TBS(pH 7.3, 0.5% BSA) 버퍼에 보관되며, -20°C에서 보관해야 합니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence SNCPDGQSTAKT |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933602 |
Product Specific Information
- The immunizing peptide represents part of the extracellular domain and does not overlap any known glycosite.
- This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:4,000.
Target Information
ICAM-1 (CD54) is an 85–110 kDa single-chain type I integral membrane glycoprotein composed of an extracellular domain with five immunoglobulin superfamily repeats, a transmembrane region, and a cytoplasmic domain.
It has seven potential N-linked glycosylation sites and shares significant sequence homology with ICAM-2 (CD102) and ICAM-3 (CD50).
ICAM-1 binds to integrins such as CD11a/CD18 (LFA-1) and CD11b/CD18 (Mac-1), and serves as a receptor for Rhinovirus.
It is expressed on activated endothelial cells, epithelial cells, fibroblasts, chondrocytes, B and T lymphocytes, monocytes, macrophages, dendritic cells, and neutrophils. Expression increases upon inflammation and is also observed in some carcinoma and melanoma cells. Soluble ICAM-1 is detectable in plasma and elevated in various inflammatory syndromes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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