
Thermo Fisher Scientific Geminin/DNA Replication Inhibitor Monoclonal Antibody (CPTC-GMNN-1)
Geminin 단백질을 표적하는 인간 반응성 마우스 단클론 항체. IHC, ICC/IF, Peptide Array 등 다양한 응용에 적합. 단백질 A/G로 정제된 액상형 항체이며, 200 µg/mL 농도로 제공. DNA 복제 억제 연구용으로 최적화된 제품.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1–2 µg/mL
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CPTC-GMNN-1 |
| Immunogen | Recombinant human full-length protein (GMNN, UniProt ID: O75496-1, antigen range: 1–209) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): Incubate antibody for 30 min at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 min at 95°C, followed by cooling at room temperature for 20 min.
Target Information
GMNN inhibits DNA replication by preventing incorporation of the MCM complex into the prereplication complex (pre-RC).
It is degraded during the mitotic phase of the cell cycle, and its destruction at the metaphase–anaphase transition permits replication in the succeeding cell cycle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: 51053-MSM1-P0_GMNN_O75496-1_House_mouse.svg, 51053-MSM1-P0_GMNN_O75496-1_House_mouse_PDP.jpeg)
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