Thermo Fisher Scientific Geminin/DNA Replication Inhibitor Monoclonal Antibody (CPTC-GMNN-1)
Geminin 단백질을 표적하는 단클론 항체로, 인간 시료에 반응. IHC, ICC/IF, Peptide Array 등 다양한 응용 가능. Recombinant full-length human GMNN을 면역원으로 사용. 단백질 A/G로 정제된 액상 형태로 제공되며, -20°C 이하에서 보관 권장.
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- 51053-MSM1-P1ABX
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1–2 µg/mL
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CPTC-GMNN-1 |
| Immunogen | Recombinant human full-length protein (GMNN, UniProt ID: O75496-1, Range: 1–209) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Immunohistochemistry (PFA fixed): Incubate antibody for 30 minutes at room temperature.
Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.
Target Information
GMNN inhibits DNA replication by preventing the incorporation of the MCM complex into the prereplication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle, and its destruction at the metaphase–anaphase transition permits replication in the succeeding cell cycle.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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