Thermo Fisher Scientific CD19 (B-Lymphocyte Marker) Monoclonal Antibody (CD19/3117)
CD19 단백질을 인식하는 마우스 단일클론 항체로, 인간 시료에 반응합니다. IHC, ELISA 등 다양한 어세이에 사용 가능하며, 단백질 A/G로 정제된 액상 형태입니다. 보존제 없이 PBS(pH 7.4)에 보관하며, -20°C에서 보관하십시오.
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- 930-MSM7-P1ABX
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Applications and Tested Dilutions
| Application | Tested Dilution | Notes |
|---|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL | |
| ELISA | Assay-dependent | |
| Peptide Array | Assay-dependent |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CD19/3117 |
| Immunogen | Recombinant fragment of human CD19 protein (around aa96–281) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD19 is a member of the immunoglobulin superfamily and has two Ig-like domains. It is expressed on nearly all peripheral B cells defined by kappa or lambda light chain expression. CD19 is also found on some myeloid leukemia cells, particularly of monocytic lineage. It is considered the earliest and broadest B cell-restricted antigen.
The CD19 receptor acts as an important regulator of normal and malignant B cell proliferation and is expressed in all B cell precursor leukemias. It functions as a signal-amplifying coreceptor for the B cell receptor (BCR) and can also signal independently. Mutations in the CD19 gene can lead to hypogammaglobulinemia, while overexpression can cause B cell hyperactivity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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