Thermo Fisher Scientific GFAP Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Reconstitution: 25 µL, 50 µL, or 0.2 mL double distilled water (DDW), depending on sample size
• Ships as a lyophilized powder at room temperature
• Upon arrival, store at -20°C
• Reconstituted solution can be stored at 4°C for up to 1 week
• For longer storage, aliquot and keep at -20°C
• Avoid multiple freeze/thaw cycles
• Centrifuge all antibody preparations before use (10,000 × g, 5 min)

Target Information

GFAP (Glial fibrillary acidic protein) is a class III intermediate filament protein expressed in astrocytes and certain astroglia of the central nervous system, satellite cells of peripheral ganglia, and non-myelinating Schwann cells. Neural stem cells also express GFAP strongly.
GFAP antibodies are useful markers for astrocytic cells and brain tumors derived from astrocytes. GFAP is additionally found in lens epithelium, Kupffer cells of the liver, salivary tumors, and erythrocytes.
GFAP serves as a marker to distinguish astrocytes from other glial cells during development. Mutations in the GFAP gene cause Alexander disease, a rare astrocyte disorder in the CNS. Alternative splicing produces multiple transcript variants encoding distinct isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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