Thermo Fisher Scientific TRPC6 Polyclonal Antibody
TRPC6 단백질을 타겟으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC(Paraffin)에 적합하며, Human과 Mouse 시료에 반응. 고순도 항원 친화 크로마토그래피 정제, 액상 형태로 안정적 저장 가능.
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Thermo Fisher Scientific TRPC6 Polyclonal Antibody
Applications and Tested Dilution
- Western Blot (WB): 1:500–1:3,000
- Immunohistochemistry (Paraffin) (IHC (P)): 1:100–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a region within amino acids 868–931 of Human TRPC6 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 40% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2545576 |
Product Specific Information
- Recommended positive controls: 293T, A431, H1299, HeLaS3, HepG2, Raji, A549, A549 membrane fraction extract
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Trpc6 forms a receptor-activated calcium channel in the cell membrane. The Trpc6 channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of the Trpc6 channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium.
Defects in the Trpc6 gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). Trpc6 belongs to the mammalian transient receptor potential (TRP) superfamily, divided into three major families, including the canonical TRP (TRPC) family. Members of this family share activation through PLC-coupled receptors and are components of receptor-regulated cation channels in various cell types.
The TRPC6/6/7 subfamily can be activated by diacylglycerol (DAG) analogs, suggesting a mechanism of activation via PLC-coupled receptors. When expressed in transfected cells, Trpc6 acts as a non-selective store-independent receptor-activated cation channel, activated by DAG in a PKC-independent manner and insensitive to IP3 activation. Increasing evidence indicates that Trpc6 encodes endogenous DAG-activated receptor-operated cation channels in vivo.
Diseases associated with TRPC6 include Glomerulosclerosis, Focal Segmental, 2 and Focal Segmental Glomerulosclerosis.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA5-28100_TRPC6_Q9Y210-1_Rabbit.svg, PA5-28100_TRPC6_Q9Y210-1_Rabbit_PDP.jpeg)
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