Thermo Fisher Scientific Periostin (POSTN) Monoclonal Antibody (POSTN, 3503)
Human Periostin(POSTN) 단백질을 인식하는 Mouse monoclonal antibody로, IHC(P) 및 Peptide Array에 사용 가능. Recombinant fragment(aa193-326)를 면역원으로 제작. Protein A/G 정제, 4°C 보관, 연구용 전용.
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- 10631-MSM3-P1
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | POSTN, 3503 |
| Immunogen | Recombinant fragment (around aa193–326) of human POSTN protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Immunohistochemistry (PFA fixed):
Incubate antibody for 30 minutes at room temperature.
Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.
Target Information
Periostin (PN), also known as osteoblast-specific factor 2 (OSF-2), is a disulfide-linked, secreted protein originally identified as an osteoblast-specific factor. It binds heparin and serves as a ligand for αVβ3 and αVβ5 integrins.
In preosteoblasts, Periostin functions as a cell adhesion molecule, promoting osteoblast recruitment, spreading, and attachment. It is mainly expressed in the lower gastrointestinal tract, aorta, stomach, placenta, uterus, and breast tissues, but is upregulated in epithelial ovarian tumors and overexpressed in breast cancer.
Expression of Periostin is increased by bone morphogenetic protein (BMP2) and transforming growth factor beta 1 (TGF-β1). The protein contains a signal sequence, a cysteine-rich domain, four fasciclin-like repeats, and a C-terminal domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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