Thermo Fisher Scientific OCRL Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000
• Publications: [참고 없음]

Product Specifications

Product Specific Information

Predicted to react with Mouse samples.

Target Information

The inositol polyphosphate 5-phosphatases selectively remove the phosphate from the 5-position of various phosphatidylinositols, which generate second messengers in response to extracellular signals.
OCRL1 is a type II 5-phosphatase that is mutated in the oculocerebrorenal syndrome of Lowe (OCRL). OCRL is a rare X-linked disorder characterized by congenital cataracts, mental retardation, muscular hypotonia, and renal tubular dysfunction.
OCRL1 has a high affinity for phosphatidylinositol 4,5-bisphosphate as well as inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate as substrates.
OCRL1 is localized to the Golgi complex and is thought to be part of the trans-Golgi network (TGN), suggesting a role in protein sorting and trafficking within the cell.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.