Thermo Fisher Scientific OCRL Polyclonal Antibody
Thermo Fisher Scientific의 OCRL 폴리클로날 항체는 인간 OCRL 유래 합성 펩타이드로 제작된 Rabbit IgG 항체입니다. Western blot에 최적화되어 있으며, 마우스 샘플에서도 반응이 예측됩니다. 액상 형태로 제공되며 -20°C에서 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
- Publications: [참고 없음]
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human OCRL |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2691621 |
Product Specific Information
Predicted to react with Mouse samples.
Target Information
The inositol polyphosphate 5-phosphatases selectively remove the phosphate from the 5-position of various phosphatidylinositols, which generate second messengers in response to extracellular signals.
OCRL1 is a type II 5-phosphatase that is mutated in the oculocerebrorenal syndrome of Lowe (OCRL). OCRL is a rare X-linked disorder characterized by congenital cataracts, mental retardation, muscular hypotonia, and renal tubular dysfunction.
OCRL1 has a high affinity for phosphatidylinositol 4,5-bisphosphate as well as inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate as substrates.
OCRL1 is localized to the Golgi complex and is thought to be part of the trans-Golgi network (TGN), suggesting a role in protein sorting and trafficking within the cell.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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