Thermo Fisher Scientific ICAM-3 Monoclonal Antibody (MEM-04)
CD50(ICAM-3)에 특이적인 MEM-04 마우스 단클론 항체로 인간 백혈구, 내피세포, 랑게르한스 세포에서 발현되는 ICAM-3 단백질을 인식합니다. IHC, Flow Cytometry, Functional Assay에 적합하며 DC-SIGN 결합 차단 기능을 가집니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 10 µg/mL | - |
| Flow Cytometry (Flow) | 1–4 µg/mL | - |
| Functional Assay (Functional) | Assay-dependent | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-04 |
| Immunogen | Leukocytes from a patient suffering from LGL type leukemia |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1072540 |
Product Specific Information
This antibody reacts with an extracellular epitope of CD50 (ICAM-3), a 120–130 kDa type I membrane protein (immunoglobulin supergene family) expressed on leukocytes, endothelial cells, and Langerhans cells; it is negative on platelets and erythrocytes.
The MEM-04 clone blocks DC-SIGN (CD209) binding to ICAM-3 (epitope in D1).
Functional Application: Blocking.
Target Information
CD50 (intracellular adhesion molecule 3, ICAM-3) is a transmembrane glycoprotein expressed by leukocytes and serves as a counter-receptor for the lymphocyte function-associated antigen (LFA)-1 integrin.
It functions as an adhesive molecule mediating contact between T cells and antigen-presenting cells, regulates LFA-1 affinity for ICAM-1, and induces T cell activation and proliferation.
ICAM-3 plays an essential role in initiating immune responses on both T cells and antigen-presenting cells, and interacts with CD209 (DC-SIGN), a C-type lectin of dendritic cells and macrophages, facilitating communication between dendritic cells and granulocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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