Thermo Fisher Scientific IL1F6 Polyclonal Antibody
IL1F6 (IL-36α) 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ELISA 등 다양한 응용에 적합. 항원 친화 크로마토그래피로 정제되었으며, PBS 및 0.02% sodium azide 용액에 보관. 인체 시료 반응성, 연구용 전용.
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Thermo Fisher Scientific IL1F6 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-Dependent |
| ELISA | Assay-Dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | IL-36A antibody for an 11 amino acid peptide near the carboxy terminus of human IL-36A. The immunogen is within the last 50 amino acids of IL-36A. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2718631 |
Target Information
The IL-1 family consists of 11 structurally related ligands, including IL-36α (IL-1F6), IL-36β (IL-1F8), and IL-36γ (IL-1F9).
IL-36α is highly expressed in psoriatic plaques and uniquely found in T cells, monocytes, and B cells. It is primarily localized in skin and lymphoid tissues, with lower expression in fetal brain, trachea, stomach, and intestine.
IL-36α signals through IL-1Rrp2 (IL-1R6) and IL-RAcP receptors, activating NF-kappaB and MAPK pathways to induce proinflammatory cytokines such as IL-6, IL-8, BD-2, and BD-3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일: PA5-72777_IL1F6_Q9UHA7-1_Rabbit.svg, PA5-72777_IL1F6_Q9UHA7-1_Rabbit_PDP.jpeg)
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