Thermo Fisher Scientific ARTS1 Polyclonal Antibody
Thermo Fisher Scientific의 ARTS1 Polyclonal Antibody는 인간 및 생쥐에서 반응하며, ERAP1 단백질을 표적하는 토끼 IgG 항체입니다. Western blot, IHC, ELISA 등에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용됩니다.
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Applications
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1.0–2.0 µg/mL | |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-Dependent | |
| ELISA | Assay-Dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | 19 amino acid peptide near the carboxy terminus of human ERAP1 (amino acids 730–780) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2718626 |
Target Information
The endoplasmic reticulum aminopeptidase 1 (ERAP1) is a 120 kDa protein localized in the ER lumen. It removes NH₂-terminal residues from antigenic precursors for MHC class I peptide presentation. ERAP1 trims peptides of 9 or more amino acids to the optimal length (8–11 residues) for MHC class I presentation. It is induced by interferon-gamma and maps to chromosome 5q15.
ERAP1 is also known as:
- Adipocyte-derived leucine aminopeptidase (A-LAP)
- Puromycin-insensitive leucine-specific aminopeptidase (PILS-AP)
- Aminopeptidase regulator of TNFR1 shedding (ARTS-1)
A-LAP may regulate bioactive peptides such as angiotensin II, influencing blood pressure. PILS-AP is associated with angiogenesis by regulating endothelial cell proliferation and migration, while ARTS-1 promotes TNFR1 shedding. Further research is required to fully elucidate the functions of this protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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