Thermo Fisher Scientific IL1F9 Polyclonal Antibody

Applications

Product Specifications

Target Information

Cytokine that binds to and signals through the IL1RL2/IL-36R receptor, activating NF-kappa-B and MAPK signaling pathways in target cells. It is part of the IL-36 signaling system, contributing to local inflammatory responses at epithelial barriers, similar to the IL-1 system with which it shares the coreceptor IL1RAP.

Involved in skin inflammatory responses by acting on keratinocytes, dendritic cells, and indirectly on T-cells to drive tissue infiltration, cell maturation, and proliferation. In cultured keratinocytes, it induces expression of macrophage, T-cell, and neutrophil chemokines (CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20, CXCL1), and stimulates its own expression along with TNF-alpha, S100A7/psoriasin, and inducible NOS.

May play a role in proinflammatory responses during neutrophilic airway inflammation by activating MAPKs and NF-kappa B in primary lung fibroblasts, stimulating IL-8, CXCL3, and Th17 chemokine CCL20 expression. Also potentially involved in innate immune responses to fungal pathogens such as Aspergillus fumigatus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 없음)