Thermo Fisher Scientific Adeno-Associated Virus Capsid Protein Polyclonal Antibody
AAV 캡시드 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체. Western blot, ELISA, Immunoprecipitation에 사용 가능. 항원 친화 크로마토그래피로 정제된 Rabbit IgG 형태. 연구용으로만 사용 가능.
- 카탈로그번호
- AAVCAP-121AP
- 판매단위
- pk
카탈로그
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Applications 및 Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Virus |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids within region 200–250 on rat 5-hydroxytryptamine receptor 1A protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Proprietary buffer with 30% glycerol |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, consisting of 60 copies of three size variants of the capsid protein VP1, VP2, and VP3 which differ in their N-terminus.
The capsid encapsulates the genomic ssDNA. It binds to host cell heparan sulfate and uses host ITGA5-ITGB1 as coreceptor on the cell surface to provide virion attachment to target cell.
This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Binding to the host receptor also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and putative nuclear localization signal(s).
VP1 N-terminus might serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell and might contribute to virus transport to the nucleus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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