Thermo Fisher Scientific GLRA1 Polyclonal Antibody
GLRA1 단백질을 인식하는 Rabbit Polyclonal 항체로, 인간, 생쥐, 랫트 시료에 반응합니다. Western blot, IHC, ICC/IF에 사용 가능하며, 합성 펩타이드를 면역원으로 제작되었습니다. 고순도의 친화 크로마토그래피 정제 제품으로, PBS/glycerol 버퍼에 보관됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human GLRA1 (Accession P23415), corresponding to amino acid residues S354–A404 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852065 |
Product Specific Information
This antibody detects endogenous levels of total GLRA1.
Target Information
GLRA1 is a subunit of a pentameric inhibitory glycine receptor that mediates postsynaptic inhibition in the central nervous system. Defects in GLRA1 are associated with startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. Multiple transcript variants encoding different isoforms have been identified for GLRA1. Glycine receptors (GlyR) containing GLRA1 belong to the cys-loop family of ligand-gated ion channels, mediating the inhibitory effects of glycine. GLRA1 is widely distributed throughout the CNS, particularly in the hippocampus, spinal cord, and brain stem. Diseases associated with GLRA1 include Hyperekplexia, Hereditary 1, and Hyperekplexia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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