Thermo Fisher Scientific GRPR Polyclonal Antibody
GRPR 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(P)에서 사용 가능. 인간, 마우스, 랫트 반응성. 합성 펩타이드 면역원 기반으로 제작되었으며, 액상 형태로 1 mg/mL 농도. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human GRPR (Accession P30550), corresponding to amino acid residues V177–S227. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2852064 |
Product Specific Information
This antibody detects endogenous levels of total GRPR.
Target Information
Gastrin-releasing peptide (GRP) regulates various functions of the gastrointestinal and central nervous systems, including:
- Release of gastrointestinal hormones
- Smooth muscle cell contraction
- Epithelial cell proliferation
GRP acts as a potent mitogen for neoplastic tissues. Its effects are mediated through the gastrin-releasing peptide receptor (GRPR), a glycosylated 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. GRPR is aberrantly expressed in various cancers including lung, colon, and prostate. A balanced translocation involving chromosome 8 and chromosome X within the GRPR gene has been identified in an individual with autism and multiple exostoses.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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