Thermo Fisher Scientific PIAS1 Recombinant Rabbit Monoclonal Antibody (ARC1116)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

ARC1116

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 3-101 of human PIAS1 (O75925) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PIAS1,uniProtId:O75925-1,ncbiNodeId:9606,antigenRange:3-101,antigenLength:651,antigenImageFileName:MA5-35571_PIAS1_O75925-1_Rabbit.svg,antigenImageFileNamePDP:MA5-35571_PIAS1_O75925-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.9 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2849471

Product Specific Information

Immunogen sequence: DSAELKQMVM SLRVSELQVL LGYAGRNKHG RKHELLTKAL HLLKAGCSPA VQMKIKELYR RRFPQKIMTP ADLSIPNVHS SPMPATLSPS TIPQLTYDG

Target Information

PIAS1 functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. This protein plays a crucial role in transcriptional coregulation of various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in androgen receptor initiation and maintenance of spermatogenesis. The effects of transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.