Thermo Fisher Scientific TNNI2 Recombinant Rabbit Monoclonal Antibody (ARC1114)
TNNI2 단백질을 인식하는 토끼 단클론 항체로 Western blot, ICC/IF, ELISA에 적합합니다. 고순도의 재조합 항체로 HEK293 세포에서 발현되었으며, 다양한 종(마우스, 랫트)에 반응합니다. 안정한 액상 형태로 -20°C 보관이 권장됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC1114 |
| Immunogen | Synthetic peptide corresponding to amino acids 83–182 of human Troponin I2 (TNNI2, UniProt ID: P48788) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.68 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS (pH 7.3), 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849469 |
Product Specific Information
Immunogen sequence:
EVRVQKTSKE LEDMNQKLFD LRGKFKRPPL RRVRMSADAM LKALLGSKHK VCMDLRANLK QVKKEDTEKE RDLRDVGDWR KNIEEKSGME GRKKMFESES
Target Information
This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C, and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction.
Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function.
In addition to muscle tissues, this protein is found in corneal epithelium and cartilage where it acts as an inhibitor of angiogenesis, and in the mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha.
This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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