Thermo Fisher Scientific Desmoglein 3 Recombinant Rabbit Monoclonal Antibody (ARC1190)
Desmoglein 3 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot, ICC/IF, ELISA에 적합합니다. HEK293 세포 발현 시스템에서 생산되며, 높은 특이성과 재현성을 제공합니다. 인간 및 마우스 시료에 반응하며 연구용으로 사용됩니다.
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Thermo Fisher Scientific Desmoglein 3 Recombinant Rabbit Monoclonal Antibody (ARC1190)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC1190 |
| Immunogen | Synthetic peptide corresponding to amino acids 900–999 of human Desmoglein 3 (UniProt ID: P32926) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.8 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS (pH 7.3), 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849582 |
Product Specific Information
Immunogen sequence:
TLSGSQGASA LSTSGSVQPA VSIPDPLQHG NYLVTETYSA SGSLVQPSTA GFDPLLTQNV IVTERVICPI SSVPGNLAGP TQLRGSHTML CTEDPCSRLI
Target Information
Desmoglein 3 (Dsg3), also known as Cadherin family member 6 (CDHF6), is part of the desmosomal cadherin family and plays a crucial role in cell-cell adhesion. It is predominantly expressed in stratified squamous epithelium, including skin, oral mucosa, and esophagus. Desmoglein 3 is identified as the autoantigen of pemphigus vulgaris (PV), a life-threatening autoimmune disease. Binding of anti-Desmoglein 3 autoantibodies results in loss of cell adhesion, clinically manifesting as blisters and histologically as suprabasilar acantholysis.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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