Thermo Fisher Scientific Phospho-ARK5 (Ser600) Polyclonal Antibody
Phospho-ARK5 (Ser600) 폴리클로날 항체로, 인간, 마우스, 랫트 시료에서 인산화된 NUAK1(Ser600)을 특이적으로 검출합니다. Western blot 및 IHC(P)에서 사용 가능하며, 고순도의 rabbit IgG 항체로 연구용에 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human NUAK1 (Accession O60285), corresponding to amino acid residues around phosphorylated Ser600 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817305 |
Product Specific Information
This antibody detects endogenous levels of NUAK1 only when phosphorylated at Ser600.
Target Information
NUAK1 (ARK5) is a serine/threonine kinase involved in multiple cellular processes. Overexpression of this kinase has been linked to tumor invasion and metastasis, particularly in colorectal cancer. It regulates cellular senescence and ploidy by phosphorylating LATS1 at Ser-464, thereby affecting its stability. NUAK1 also controls cell adhesion through regulation of the myosin protein phosphatase 1 (PP1) complex by phosphorylating the PPP1R12A subunit, which interacts with 14-3-3 proteins, reducing dephosphorylation of myosin MLC2. Additionally, NUAK1 participates in the DNA damage response by phosphorylating p53 at Ser-15 and Ser-392, contributing to transcriptional activation of CDKN1A/WAF1. It may act as a tumor malignancy-associated factor under AKT1 regulation and phosphorylation, suppressing Fas-induced apoptosis via phosphorylation of CASP6, and modulating UV-induced DNA damage responses through CDKN1A phosphorylation in association with STK11.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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