Thermo Fisher Scientific PIASy Polyclonal Antibody
PIASy 단백질을 검출하기 위한 Rabbit Polyclonal Antibody로 Western blot 및 Immunocytochemistry에 적합합니다. Human, Mouse, Rat에 반응하며 Protein G로 정제된 액상 형태입니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific PIASy Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 3–5 µg/mL |
| Immunocytochemistry (ICC/IF) | 1:10–1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptides QLVQFDCSPELFKKIKE and KAVQVVLRICYS, corresponding to amino acids 44–60 and 187–198 of Human PAIAS gamma |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 0.05% BSA, 0.2% gelatin |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1959259 |
Product Specific Information
PA1-29456 detects PAIAS gamma from human samples.
Target Information
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor.
Plays a crucial role as a transcriptional coregulator in various cellular pathways, including:
- STAT pathway
- p53/TP53 pathway
- Wnt pathway
- Steroid hormone signaling pathway
Involved in gene silencing and mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4, and RNF168.
In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations.
Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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