Thermo Fisher Scientific ENO1 Polyclonal Antibody, MaxPab

Applications

• Western Blot (WB): Tested dilution 1–5 µg/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MSILKIHARE IFDSRGNPTV EVDLFTSKGL FRAAVPSGAS TGIYEALELR DNDKTRYMGK GVSKAVEHIN KTIAPALVSK KLNVTEQEKI DKLMIEMDGT ENKSKFGANA ILGVSLAVCK AGAVEKGVPL YRHIADLAGN SEVILPVPAF NVINGGSHAG NKLAMQEFMI LPVGAANFRE AMRIGAEVYH NLKNVIKEKY GKDATNVGDE GGFAPNILEN KEGLELLKTA IGKAGYTDKV VIGMDVAASE FFRSGKYDLD FKSPDDPSRY ISPDQLADLY KSFIKDYPVV SIEDPFDQDD WGAWQKFTAS AGIQVVGDDL TVTNPKRIAK AVNEKSCNCL LLKVNQIGSV TESLQACKLA QANGWGVMVS HRSGETEDTF IADLVVGLCT GQIKTGAPCR SERLAKYNQL LRIEEELGSK AKFAGRNFRN PLAK

Target Information

Enolase (2-phosphogly-cerate hydrolyase or phosphopyruvate hydrates) is a glycolytic enzyme that catalyzes the dehydration and conversion of 2-phosphoglycerate to phosphoenolpyruvate. It comprises three distinct subunits: alpha, beta, and gamma.
Non-neuronal Enolase (ENO1) is an isoform composed of two alpha subunits. The ENO1 gene also encodes a shorter monomeric structural lens protein, tau-crystallin.
This multifunctional enzyme plays roles in glycolysis, growth control, hypoxia tolerance, and allergic responses. It may also act as a receptor and activator of plasminogen on cell surfaces such as leukocytes and neurons, stimulating immunoglobulin production.

ENO1 serves as a diagnostic marker for various tumors and, in its alpha/gamma heterodimeric form, as a marker for hypoxic brain injury after cardiac arrest. It is also a marker for endometriosis.
Antibodies against alpha-enolase are found in sera from patients with cancer-associated retinopathy syndrome (CAR) and are identified as autoantigens in Hashimoto encephalopathy (HE), associated with Hashimoto thyroiditis (HT).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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