Thermo Fisher Scientific CD33 Monoclonal Antibody (HIM3-4), Biotin

Applications

Flow Cytometry (Flow)

• Tested Dilution: 1–12 µg/mL
• Publications: View 2 publications

Miscellaneous PubMed (Misc)

• Tested Dilution: –
• Publications: View 1 publication

Product Specifications

Product Specific Information

This antibody reacts with an extracellular epitope of CD33, a 67 kDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells, and mast cells. It is absent on platelets, lymphocytes, erythrocytes, and hematopoietic stem cells.

Target Information

CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that recruit protein tyrosine phosphatases SHP-1 and SHP-2, and are involved in ubiquitin-mediated receptor removal from the cell surface.
CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues on cell surface glycans, and serves as a therapeutic target for acute myeloid leukemia. It is present on granulocyte and macrophage precursors in bone marrow, but not on pluripotent stem cells. CD33 is also a useful marker for peripheral monocytes and for distinguishing myelogenous leukemia cells from lymphoid or erythroid leukemias.
Diseases associated with CD33 dysfunction include gallbladder lymphoma and extracutaneous mastocytoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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