Thermo Fisher Scientific MMP-2 Polyclonal Antibody
MMP-2 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot, IHC, ICC, Flow cytometry, ELISA 등 다양한 응용에 적합. Human, Mouse, Rabbit, Rat에 반응하며 Protein A로 정제된 액상 항체. -20°C 보관, 연구용 전용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) [IHC (P)] | 1:200 |
| Immunohistochemistry (Frozen) [IHC (F)] | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rabbit, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human MMP-2, amino acids 561–660 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Matrix metalloproteinases (MMPs) are proteolytic enzymes capable of degrading connective tissue components. They share a common activation mechanism, a conserved metal-binding active site, and are inhibited by tissue inhibitors of metalloproteinases (TIMPs). MMPs and TIMPs play important roles in angiogenesis regulation.
MMP-2 is synthesized as a 631-amino acid proenzyme, activated by cleavage of the first 80 amino acids, and includes propeptide, catalytic, and hemopexin domains. MMPs can degrade extracellular matrix components such as collagens, fibronectin, laminin, and basement membrane glycoproteins. Structurally, they possess a signal peptide, propeptide, and catalytic domain with a conserved zinc-binding site. Functionally, MMP-2 is involved in tissue remodeling. Mutations in the MMP-2 gene are associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms of MMP-2 have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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