Thermo Fisher Scientific SQRDL Polyclonal Antibody
Thermo Fisher Scientific의 SQRDL Polyclonal Antibody는 Human 및 Mouse 시료에 반응하는 Rabbit IgG 기반 항체입니다. Western blot, IHC, ICC/IF 등에 사용 가능하며, 고순도 항원 친화 크로마토그래피로 정제되었습니다. 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SQRDL. Recombinant protein control fragment (Product #RP-89842). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.30 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2647905 |
Product Specific Information
Immunogen sequence:
TSPVADAAGW VDVDKETLQH RRYPNVFGIG DCTNLPTSKT AAAVAAQSGI LDRTISVIMK NQTPTKKYDG YTSCPLVTGY NRVILAEFDY KAEPLETFPF DQSKERLSMY LMKADLMPFL YWNMMLRGYW G
Highest antigen sequence identity to the following orthologs:
- Mouse: 89%
- Rat: 93%
Target Information
SQRDL (Sulfide: quinone oxidoreductase, mitochondrial) catalyzes the oxidation of hydrogen sulfide with the help of a quinone. Although the SQRDL precursor protein displays a molecular weight of 50 kDa, a prominent band at about 46 kDa is detected by western blot. This discrepancy reflects the cleavage of an N-terminal targeting sequence of 4 kDa during import into the mitochondria. SQRDL is one of the enzymes involved in H₂S signaling in neurons, oligodendrocytes, and endothelial cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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