Thermo Fisher Scientific RLBP1 Polyclonal Antibody, MaxPab

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MSEGVGTFRM VPEEEQELRA QLEQLTTKDH GPVFGPCSQL PRHTLQKAKD ELNEREETRE EAVRELQEMV QAQAASGEEL AVAVAERVQE KDSGFFLRFI RARKFNVGRA YELLRGYVNF RLQYPELFDS LSPEAVRCTI EAGYPGVLSS RDKYGRVVML FNIENWQSQE ITFDEILQAY CFILEKLLEN EETQINGFCI IENFKGFTMQ QAASLRTSDL RKMVDMLQDS FPARFKAIHF IHQPWYFTTT YNVVKPFLKS KLLERVFVHG DDLSGFYQEI DENILPSDFG GTLPKYDGKA VAEQLFGPQA QAENTAF

Target Information

Cellular retinaldehyde-binding protein (CRALBP) plays a key role in the regeneration of 11-cis-retinal for use in rod visual pigments such as opsin and rhodopsin.
Once 11-cis-retinal is photoisomerized in the rod outer segment, it is converted to all-trans-retinal and further modified into all-trans-retinol.
All-trans-retinol then diffuses into the retinal pigment epithelium (RPE) to be converted back to 11-cis-retinol and further oxidized into 11-cis-retinal, both catalyzed by CRALBP.

Genetic mutations involving CRALBP’s lack of function have been linked to visual diseases such as Bothnia dystrophy, retinitis punctata albescens, retina pigmentosa, and Newfoundland rod-cone dystrophy.
The presence of CRALBP serves as a marker for RPE and Müller glial cells of the retina.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.