Thermo Fisher Scientific CHST15 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
GIVRLRDGLR DRYPVEDYLD LFDLAAHQIH QGLQASSAKE QSKMNTIIIG EASASTMWDN NAWTFFYDNS TDGEPPFLTQ DFIHAFQPNA RLIVMLRDPV ER

Sequence identity:

• Mouse: 93%
• Rat: 92%

Target Information

GALNAC4S-6ST is a sulfotransferase that transfers sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to the C-6 hydroxyl group of the GalNAc 4-sulfate residue of chondroitin sulfate A, forming chondroitin sulfate E containing GlcA-GalNAc(4,6-SO₄) repeating units.
It also transfers sulfate to a unique non-reducing terminal sequence, GalNAc(4SO₄)-GlcA(2SO₄)-GalNAc(6SO₄), yielding a highly sulfated structure similar to that found in thrombomodulin chondroitin sulfate.
GALNAC4S-6ST may also act as a B-cell receptor involved in BCR ligation-mediated early activation and regulatory signaling for B-cell development and RAG expression, though in vivo evidence remains unclear.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.