Thermo Fisher Scientific Progesterone Receptor Recombinant Rabbit Monoclonal Antibody (JF0549)

Applications and Tested Dilution

Product Specifications

Product Specific Information

This product is predicted to work in Western Blot at a dilution of 1:1,000.

Target Information

The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. It mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy.
PR exists as a 94 kDa protein (Form A) or a 120 kDa protein (Form B) due to alternative translation initiation sites.
PR-B is the transcriptionally active form responsible for gene activation related to endometrial maintenance, pregnancy, and inhibition of ovulation.
PR-A lacks 165 amino acids at the N-terminus, exposing an inhibitory domain that represses steroid hormone transcriptional activity.
In its inactive state, PR forms a multiprotein complex with heat shock proteins and immunophilins. Upon progesterone binding, conformational change allows dimerization and DNA binding to progesterone response elements (PRE), activating transcription.
A null mutation in the PGR gene leads to reproductive abnormalities.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.