Thermo Fisher Scientific CD63 Monoclonal Antibody (OTI1D12), TrueMAB

Applications and Tested Dilutions

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

CD63 (LAMP-3, lysosome-associated membrane protein-3) is a tetraspanin family glycoprotein localized in late endosomes, lysosomes, and secretory vesicles of various cell types. It is also found on the plasma membrane following cell activation and is widely used as a basophil activation marker.

In mast cells, CD63 expression does not require activation. CD63 interacts with integrins, influencing phagocytosis and cell migration, and is involved in H/K-ATPase trafficking and ROMK1 channel regulation. It also functions as a T-cell costimulation molecule.

CD63 expression can serve as a prognostic indicator in early-stage carcinomas. It is expressed on activated platelets, monocytes, macrophages, and weakly on granulocytes, B, and T cells. CD63 is identical to the melanoma-associated antigen ME491 and the platelet antigen PTLGP40.
Diseases associated with CD63 dysfunction include melanoma and Hermansky-Pudlak Syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.