Thermo Fisher Scientific ARC Polyclonal Antibody
ARC 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 최적화되어 있습니다. 합성 펩타이드(aa 2-18)를 면역원으로 제작되었으며, 1 mg/mL 농도의 액상 형태입니다. 단기 4°C, 장기 -20°C에서 보관하며, HeLa 세포 용해물이 권장 양성 대조군입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 2–18 of ARC |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2060344 |
Product Specific Information
- Recommended positive control: HeLa whole cell lysate
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
ARC (also known as NOL3 - Nucleolar protein 3) has two isoforms.
- Isoform 1: Involved in RNA splicing.
- Isoform 2: Functions as an apoptosis repressor that blocks multiple modes of cell death.
ARC inhibits extrinsic apoptotic pathways in two ways:
- Interacts with FAS and FADD upon FAS activation, blocking death-inducing signaling complex (DISC) assembly.
- Interacts with CASP8 in a mitochondria localization- and phosphorylation-dependent manner, limiting soluble CASP8 available for DISC-mediated activation.
ARC also inhibits intrinsic apoptotic pathways in response to various stresses through interactions with BAX, leading to BAX inactivation and prevention of mitochondrial dysfunction and release of pro-apoptotic factors.
Mutations affecting this gene can result in myoclonus, familial cortical.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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