Thermo Fisher Scientific CHK2 Monoclonal Antibody (8F12)
CHK2 단백질을 인식하는 Thermo Fisher Scientific의 Mouse Monoclonal Antibody (Clone 8F12). Western blot 및 Immunocytochemistry에 적합. 고순도 Protein G 정제, 1 mg/mL 농도. Human 시료 반응성, 연구용 전용 시약.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CHK2 Monoclonal Antibody (8F12)
Thermo Fisher Scientific CHK2 Monoclonal Antibody (8F12)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 8F12 |
| Immunogen | Recombinant CHK2 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787220 |
Product Specific Information
- Keep as concentrated solution.
- Positive Control: HepG2, MCF-7, or LN-Cap total cell extract.
Target Information
CHEK2 (CHK2) is a serine/threonine kinase and a component of the DNA damage checkpoint pathway. Mutations in CHK2 have been linked to cancer. CHK2 is activated by DNA damage and phosphorylates several modulators of cell cycle control, including tumor suppressor proteins.
Chk2 can phosphorylate BRCA1, allowing BRCA1 to restore survival after DNA damage.
Chk2 is a putative tumor suppressor protein, and mutations in the Chk2 gene are linked to Li-Fraumeni syndrome, a familial cancer associated with inherited mutations in TP53.
Mutations in CHK2 are also thought to confer a predisposition to sarcomas, breast cancer, and brain tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.