Thermo Fisher Scientific SEMA4D Monoclonal Antibody (3B4)

Applications

Western Blot (WB)

• Tested Dilution: 1–5 µg/mL

ELISA

• Tested Dilution: 0.3 ng/mL

Product Specifications

Product Specific Information

Sequence of this protein:

LQPLSATSLY VCGTNAFQPA CDHLNLTSFK FLGKNEDGKG RCPFDPAHSY TSVMVDGELY 
SGTSYNFLGS EPIISRNSSH SPLRTEYAIP WLNEPSFVFA DVIRKSPDSP

Target Information

Semaphorins are neuronal chemorepellants that direct pioneering neurons during nervous system development.
CD100 (also known as semaphorin 4D), a 150 kDa homodimer, is a novel semaphorin that induces B cells to aggregate and improves their viability in vitro.
CD100 modifies CD40-CD40L B cell signaling by augmenting B cell aggregation and survival and downregulating CD23 expression.
CD72 is a lymphocyte receptor for the class IV semaphorin CD100, which is involved in regulating B cell signaling.
CD100 is expressed on resting and PHA-stimulated T cells. The protein is weakly expressed on NK cells, EBV-transformed B cells, monocytes, and tumor/peripheral blood T cell lines, and at higher density on activated T cells and B cells.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.