Thermo Fisher Scientific RNASEH2A Polyclonal Antibody, MaxPab

Applications and Tested Dilution

• Western Blot (WB): 1:500–1:1,000

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MDLSELERDN TGRCRLSSPV PAVCRKEPCV LGVDEAGRGP VLGPMVYAIC YCPLPRLADL EALKVADSKT LLESERERLF AKMEDTDFVG WALDVLSPNL ISTSMLGRVK YNLNSLSHDT ATGLIQYALD QGVNVTQVFV DTVGMPETYQ ARLQQSFPGI EVTVKAKADA LYPVVSAASI CAKVARDQAV KKWQFVEKLQ DLDTDYGSGY PNDPKTKAWL KEHVEPVFGF PQFVRFSWRT AQTILEKEAE DVIWEDSASE NQEGLRKITS YFLNEGSQAR PRSSHRYFLE RGLESATSL

Target Information

Ribonucleases (RNAses) H are enzymes that hydrolyze the RNA strands of RNA/DNA hybrids. Their major role is to remove the RNA strand from RNA/DNA hybrids formed during DNA replication and repair. RNAse H2 consists of three subunits, all required for RNAse activity. Mutations in RNAse H2A or other subunits can cause Aicardi-Goutieres syndrome (AGS), a neurological disorder with symptoms similar to viral brain infections and elevated IFN-alpha levels in cerebrospinal fluid. Similar conditions occur with TREX1 mutations, suggesting that RNAse H2 and TREX1 have related roles in preventing accumulation of intracellular nucleic acids and activation of the innate immune system.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.