Thermo Fisher Scientific beta Amyloid (1-43) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: -
• View 1 publication

Immunohistochemistry (IHC)

• Tested Dilution: -
• View 2 publications

Functional Assay

• Assay-dependent

Radioimmune Assays (RIA)

• Assay-dependent

Dot blot (DB)

• Tested Dilution: 0.05–1.0 µg/mL

Product Specifications

Product Specific Information

This beta Amyloid (1-43) antibody (44-340) is purified from rabbit serum by epitope-specific affinity chromatography.
Any reactivity towards both full-length Aβ40 and Aβ42 protein has been eliminated through a series of preabsorption steps.
This antibody shows no significant cross-reactivity against Aβ40 or Aβ42.

Target Information

Amyloid beta peptide (Abeta/Beta-amyloid) is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer’s disease.
Abeta peptide is 40–43 amino acids long and generated from the beta-amyloid precursor protein (beta APP) in a two-step process:

1. Cleavage of the extracellular amino-terminal domain of beta APP by beta-secretase (BACE), an aspartyl protease activated by prohormone convertase furin.
2. Subsequent cleavage of the membrane-bound remnant by gamma-secretase, a multi-subunit complex containing presenilin-1 and -2, and associated with nicastrin.

Amyloid beta peptide forms extracellular filamentous deposits found in amyloid cores, neuritic plaques, and neurofibrillary tangles.
Abnormal accumulation is associated with Alzheimer’s disease, Lewy body dementia, Down’s syndrome, Dutch-type amyloidosis, cerebral amyloid angiopathy, and the Guam Parkinson-Dementia complex.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.