Thermo Fisher Scientific HOXD11 Polyclonal Antibody
Human HOXD11 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 최적화되어 있습니다. KLH 결합 합성 펩타이드로부터 유래하며, Protein A 및 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 187–216 amino acids from the central region of human HOXD11 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Protein A, Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2900863 |
Target Information
HOX11, also known as homeobox11 or Tcl-3, is located at the 10q24 T-cell translocation breakpoint region. It encodes a homeobox-domain-containing protein with a glycine- and proline-rich amino terminus. HOX11 is essential for spleen development and cell survival. The protein binds specific DNA sequences, localizes to the nucleus, and acts as a positive transcription activator. HOX11 is highly expressed in T-ALLs due to translocations such as t(7:10)(q35;q24) or t(10:14)(q24;q11), leading to deregulation and activation of tumor-associated genes. This gene is implicated in T-cell leukemia and lymphoid neoplasias.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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