Thermo Fisher Scientific CD41 Monoclonal Antibody (MEM-06), APC
인간 CD41(GPIIb) 항원을 인식하는 마우스 단클론 항체로 APC 형광체가 결합되어 있습니다. Flow cytometry 및 ICC/IF 분석에 적합하며, 혈소판 및 거핵세포 표지에 활용됩니다. 액상 형태로 제공되며 4°C 암소 보관이 필요합니다.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: Not specified
- View 1 publication
Flow Cytometry (Flow)
- Tested Dilution: 10 µL/100 µL whole blood or 10⁶ cells
- View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-06 |
| Immunogen | Leukocytes of patient suffering from LGL-type leukaemia |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1955286 |
Additional Formats
- Unconjugated
- Alexa Fluor 488
- Alexa Fluor 700
- Biotin
- FITC
- PE
- PerCP
- Request custom conjugation
Product Specific Information
This antibody reacts with an extracellular epitope of CD41 (GPIIb), a transmembrane glycoprotein (integrin family) composed of two chains: GPIIb alpha (heavy chain; 120 kDa) and GPIIb beta (light chain; 23 kDa). CD41 is mainly expressed on platelets and megakaryocytes.
Target Information
CD41 (platelet glycoprotein IIb, ITGA2B) consists of two subunits, alpha (120 kDa) and beta (23 kDa), which interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. CD41 is involved in platelet aggregation and blood coagulation by binding to proteins such as von Willebrand factor, fibrinogen, fibronectin, and vitronectin. It is mainly expressed in the megakaryocyte-platelet lineage and appears early in hematopoietic differentiation.
Diseases associated with CD41 dysfunction include Glansmann Thrombasthenia and Platelet type-16 bleeding disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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