Thermo Fisher Scientific KLRG1 Monoclonal Antibody (13F12F2), PE, eBioscience
인간 KLRG1 단백질을 인식하는 마우스 모노클로날 항체로, PE 형광 표지되어 유세포분석(Flow Cytometry)에 최적화됨. 13F12F2 클론으로 높은 특이성과 재현성을 제공. 인간 NK 및 T세포의 활성 억제 수용체 연구에 적합.
- 카탈로그번호
- 12-9488-42
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific KLRG1 Monoclonal Antibody (13F12F2), PE, eBioscience
Thermo Fisher Scientific KLRG1 Monoclonal Antibody (13F12F2), PE, eBioscience
Applications
- Flow Cytometry (Flow)
Tested Dilution: 5 µL (0.25 µg)/test
View 5 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Recommended Isotype Control | Mouse IgG2a kappa Isotype Control (eBM2a), PE, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 13F12F2 |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2572716 |
Available Formats
- Alexa Fluor 488
- Alexa Fluor 647
- APC
- APC-eFluor 780
- Brilliant UV 395
- Brilliant UV 737
- Brilliant Violet 480
- Brilliant Violet 786
- Functional Grade
- PE-Cyanine7
- PE-eFluor 610
- PerCP-eFluor 710
- Super Bright 600
- Super Bright 702
- Request custom conjugation
Product Specific Information
This 13F12F2 monoclonal antibody reacts with human killer cell lectin-like receptor subfamily G, member 1 (KLRG1), a type II transmembrane inhibitory receptor of the C-type lectin superfamily containing an ITIM domain. It is expressed on subsets of γδ T cells, NK (CD56dim), CD8+ and CD4+ T cells, mainly in effector/memory phenotype cells that are short-lived but capable of immediate effector function.
Cadherin-E, -N, and -R are ligands for KLRG1, and their interaction inhibits cytolytic activity and proliferation. The percentage of KLRG1-positive cells varies depending on antigen exposure.
The clones 13F12F2 and 13A2 recognize a similar epitope based on cross-blocking studies.
Applications Reported: Flow cytometric analysis.
Applications Tested: Pre-titrated and tested by flow cytometric analysis of human peripheral blood cells; use at 5 µL (0.25 µg) per test.
A test corresponds to staining a cell sample (10⁵–10⁸ cells/test) in 100 µL final volume.
Excitation: 488–561 nm; Emission: 578 nm; Laser: Blue, Green, Yellow-Green.
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
KLRG1 (Killer cell lectin-like receptor G1, MAFA, 2F1-Ag) is a homodimeric receptor of the lectin-like type 2 transmembrane family containing ITIM motifs in its cytoplasmic domain. These motifs interact with SH2 domains of phosphatases such as SHP-1. KLRG1 acts as an inhibitory receptor expressed on NK cells and certain T cells, involved in tumor and virus-infected cell lysis and immune regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.