Thermo Fisher Scientific AES Polyclonal Antibody
AES 단백질을 인식하는 Rabbit Polyclonal 항체로, WB와 ELISA에 적합합니다. Human 및 Mouse 시료에 반응하며, 고순도의 Affinity Chromatography 정제 제품입니다. 핵 내 단백질 검출에 유용하며, 안정적인 액상 형태로 제공됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–264 of human AES (NP_945320.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 8.47 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914721 |
Product Specific Information
- Positive test controls: A-549, HeLa, U-251MG, Mouse liver
- Subcellular localization: Nucleus
Immunogen sequence:
MCHKNGFPQE GGITAAFLQK RKLRLSKNHR PARAKVTEHV RGTRPGRATA GPAASTRAAG SLFFDRWGNR GPAGCRGSSH LPQQLKFTTS DSCDRIKDEF QLLQAQYHSL KLECDKLASE KSEMQRHYVM YYEMSYGLNI EMHKQAEIVK RLNGICAQVL PYLSQEHQQQ VLGAIERAKQ VTAPELNSII RQQLQAHQLS QLQALALPLT PLPVGLQPPS LPAVSAGTGL LSLSALGSQA HLSKEDKNGH DGDTHQEDDG EKSD
Target Information
Adhesion to the extracellular matrix regulates cell survival through both integrin engagement and proper cell spreading. Anoikis is the apoptosis mechanism induced by integrin detachment. Amino-terminal enhancer of split (AES) is a member of the Groucho/transducin-like enhancer of split (TLE) family of transcriptional regulators, functioning as co-repressors involved in neurogenesis, segmentation, and sex determination. AES forms a complex with Bit1 (Bcl-2 inhibitor of transcription 1), a mitochondrial protein released into the cytoplasm during apoptosis. This complex suppresses survival-promoting gene transcription controlled by the TLE family. Apoptosis induced by AES and Bit1 can be inhibited when cells attach to fibronectin via the α5β1 integrin, suggesting that the Bit1–AES pathway contributing to anoikis is regulated by integrins, particularly α5β1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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